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Crystalys is a calcium hydroxyapatite-based injectable dermal filler designed to restore facial volume and natural contours by promoting generation and deposition of natural collagen, the body's physiological soft tissue filler. The beneficial effects of Crystalys are both immediate and long lasting. Clinical results are evident for up to 2 years, depending on the volume injected, patient skin properties and age.

Crystalys advantages

  • Marketed since September 2011, with tens of thousands of syringes marketed so far, worldwide!
  • Extensive clinical experience.
  • Sound safety pro­file.
  • Safe active ingredient with over a decade of marketing experience in dermal fillers.
  • Many decades of clinical experience using Calcium Hydroxyapatite in dental, bone and surgical implants.
  • CE certified.
  • Biocompatible and biodegradable.
  • Promotes generation of natural collagen.
  • Provides a volumizing, lifting effect.


  • Calcium hydroxyapatite (55.7%) microspheres of 25-45 microns diameter, Glycerin, CMC and Phosphate buffer.
  • Crystalys is provided in a 1.25 mL pre­filled graduated syringe.



Injected areas are filled and lifted, resulting in a superb 'on the spot' outcome.

Long Term

The calcium hydroxyapatite microspheres form a scaffold supportive of fibroblast ingrowth,

which, in turn, produces and deposits new collagen, a natural volumizing agent in facial regions.

Calcium hydroxyapatite degradation is synchronous with neo-collagen deposition at the injection site,

providing a lasting, natural, full and youthful look.


Extrusion Force

The force applied by the physician while injecting


*Both materials were injected at a flow rate of 1ml/min. via a 25G/16mm needle (0.31mm inner diameter)

Microspheres morphology

  • Crystalys is comprised of round, uniform, non-porous and smooth calcium hydroxyapatite microspheres
  • The microspheres are 25-45 microns in diameter
  • The microsphere size enables easy extrusion and reduced friction flow from the syringe into the treated site
  • The microsphere diameter minimizes risk of particle migration and phagocytosis, ensuring a smooth appearance
  • At the treated site, the calcium hydroxyapatite microspheres form a scaffold which facilitates autogenous collagen growth that continues for several months


Data collected from 218 patients demonstrated

an excellent safety profile and superb performance results!




A post marketing study of 218 patients, assessed safety

and performance parameters associated with Crystalys treatment.

Safety was evaluated up to a year, on 218 patients.

Performance was evaluated on a sub-group of 73 patients,

up to 6 months.

Medical files were retrospectively analyzed and "post-treatment"

photos were obtained and scored by a trained practitioner by means

of validated clinical scales [Lemperle  Rating Scale (LRS) and

The Global Aesthetic Improvement Scale (GAIS)].

 A sub-group of 87 patients also filled a satisfaction questionnaire.

Clinical study results











Treatment Areas